Hematopoesis
A) NORMAL DEVELOPMENT
B) ABNORMAL DEVELOPMENT
LEGEND
PSC – Pluripotential stem cell
MSC – Multipotential stem cell
IPSC – Immunoreactive pluripotential stem cell
DSCE – Directed stem cell of erythropoeisis
DSCG – Directed stem cell of granulocytopoeisis
DSCM- Directed stem cell of monocytopoeisis
DSCT – Directed stem cell of trombocytopoeisis
Erythropoesis
- Proerythroblast (ProEryt) -> Basophylic erythroblast (BasoEryt) -> Polychromatic erythroblast (PolyEryt) -> Acidophylic erythroblast (AcEryt) -> Reticulocyte (Rtc) -> Erythrocyte (Eryt)
- Promegaloblast (Pro meg) -> Basophylic megaloblast (Basomeg) -> Polychromatic megaloblast (Polymeg) -> Acidophylic megaloblast (Acmeg) -> Reticulocyte (Rtc) -> Megalocyte (Meg)
Granulocytopoeisis
Myeloblast (Myb) -> Promyelocyte (pMy) -> Myelocyte (My) – Neutrophils, Eosinophilis, Basophilis -> Metamyelocyte (mMy) – Neutrophils, Eosinophilis, Basophilis -> Non-segmented granulocyte (Stab) – Neutrophils, Eosinophilis, Basophilis -> Segmented granulocyte (SegGr) – Neutrophils (Neut), Eosinophilis (Eos), Basophilis (Bas)
Monocytopoeisis
Monoblast (Mon. b) -> Promonocyte (pMon) -> Monocyte (Mon) -> Free and fixed tissue macrophage (Macro)
Trombocytopoeisis
Megakaryoblasts (Megakarb) -> Promegakaryocyte (Promegkar) -> Megakaryocyte (Megakar) -> Trombocyte (Platelet) (Plt)
Immunocytopoeisis
T-system
Pre-T-cell (PreT) -> Lymphoblast (Lymbl) -> Prolymphocyte (Prolym) -> Thymocyte (Thym) -> T-lymphocyte (T-Lym)
B-system
Pre-B-cell (PreB) -> Lymphoblast (Lymbl) -> Prolymphocyte (Prolym) -> B-lymphocyte (B-lym) -> Plasmablast (Plasmabl) -> Proplasmocyte (Proplasm) -> Plasmocyte (Plasm) -> Plasma cell